Rate versus rhythm in atrial fibrillation: and how slow do you go?
Year: 2011
Type: article
Abstract: For patients with persistent atrial fibrillation (AF), how does attempting to control sinus rhythm compare with rate control, and what should the target heart rate be? Evidence •\t Rate versus rhythm: Four meta-analyses1-4 with up to 5 trials compared rate and rhythm (N = 5239, mean age 69 years, 38 % women, mean follow-up 3.1 years).1-3 Compared with those in the rhythm-control group, patients in the rate-control group-had significantly fewer hospitalizations (54.7 % vs 67.3%, P <.01, number needed to treat [NNT] = 8)3;-had significantly reduced death, cardioembolic stroke, and intracranial hemorrhage (16.3 % vs 18.6%, P =.03, NNT = 43)2—although individual end points did not reach statistical significance; and-were less likely to be in sinus rhythm (eg, 35 % vs 63% in the largest trial).1 •\t Strict versus lenient rate: An RCT5 (N = 614, mean age 68
Source: Europe PMC (PubMed Central)
Institution: University of Alberta
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2131724119