Work

Computational Identification of Site-Specific Transcription Factors in Drosophila

Year: 2007

Type: article

Abstract: Site-specific transcription factors (TFs) recognise their target genes in a sequence- or conformation-dependent manor. In contrast to the basal TFs that are the general facilitators of gene expression, their site-specific interaction partners are tissue- or condition-specific. Thus, site-specific TFs constitute the major prerequisite for the modular expression programmes that drive metazoan development. This article deals with the computational identification of TFs (how to find them in genomes) and with online resources such as the FlyTF database of Drosophila site-specific TFs (how to find them online).

Source: Fly

DOI: 10.4161/fly.4571

Authors: Boris Adryan, Sarah A. Teichmann

Institution: MRC Laboratory of Molecular Biology

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $1,860

Funder: Medical Research Council