Associations of Non-Hodgkin Lymphoma (NHL) Risk With Autoimmune Conditions According to Putative NHL Loci
Year: 2015
Type: article
Abstract: Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwu290
Authors: Sophia S. Wang, Claire M. Vajdic, Martha S. Linet, Susan L. Slager, Jenna Voutsinas, Alexandra Nieters, Silvia de Sanjose, Wendy Cozen, Graciela S. Alarcón, Otoniel Martinez-Maza, Elizabeth E. Brown, Paige M. Bracci, Tracy Lightfoot, Jennifer Turner, Henrik Hjalgrim, John J. Spinelli, Tongzhang Zheng, Lindsay M. Morton, Brenda M. Birmann, Christopher R. Flowers, Ora Paltiel, Nikolaus Becker, Elizabeth A. Holly, Eleanor Kane, Dennis Weisenburger, Marc Maynadie, Pierluigi Cocco, Lenka Foretova, Anthony Staines, Scott Davis, Richard Severson, James R. Cerhan, Elizabeth C. Breen, Qing Lan, Angela Brooks-Wilson, Anneclaire J. De Roos, Martyn T. Smith, Eve Roman, Paolo Boffetta, Anne Kricker, Yawei Zhang, Christine Skibola, Stephen J. Chanock, Nathaniel Rothman, Yolanda Benavente, Patricia Hartge, Karin E. Smedby
Institutions: City Of Hope National Medical Center, City of Hope, Beckman Research Institute, UNSW Sydney, National Institutes of Health, Mayo Clinic, University of Freiburg, Institut Català d'Oncologia, University of Southern California, University of Alabama at Birmingham, University of California, Los Angeles, University of California, San Francisco, University of York, Macquarie University, Statens Serum Institut, University of British Columbia, Yale University, Harvard University, Emory University, Hebrew University of Jerusalem, German Cancer Research Center, Université de Bourgogne, University of Cagliari, Masaryk Memorial Cancer Institute, Dublin City University, University of Washington, Wayne State University, Simon Fraser University, Drexel University, University of California, Berkeley, Icahn School of Medicine at Mount Sinai, The University of Sydney, Karolinska Institutet
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Yale University, Compagnia di San Paolo, Beckman Research Institute, City of Hope, Health Research Board, Michael Smith Health Research BC, European Commission, University of New South Wales, University of Sydney, Karolinska Institutet, José Carreras Leukämie-Stiftung, Bundesamt für Strahlenschutz, Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona, National Institutes of Health, University of California, San Francisco, Canadian Institutes of Health Research, Medical Research Council, National Health and Medical Research Council, Cancer Council NSW, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute
Awards: G1356092923, G1463296869, DCTD Computer Support, G1799052500, G1966788416, G2038983678, G2149619933, G2310148225, G2741775799, G2798125399, EPIDEMIOLOGY OF NON-HODGKIN'S LYMPHOMA &RETROVIRAL TEST, G3970052678, A prospective analysis of peripheral blood cytokines and non-Hodgkin lymphoma, G4865969775, EPIDEMIOLOGY OF NON HODGKINS'S LYMPHOMA DATA ANALYSIS, G5439407060, Resequencing and Functional Studies to Identify Causal Gene Variants of Lymphoma, HAIR DYE USE AND RISK OF NONHODGKINS LYMPHOMA, G609966341, G625658656, G6622425196, G772794905, G7769837710, G7984774186, G8829778223, G9000325690
OpenAlex ID: W2131820684