Work

Essential function for ErbB3 in breast cancer proliferation

Year: 2004

Type: article

Abstract: The overexpression of the ErbB family of tyrosine kinase receptors is thought to be important in the development of many breast tumours. To date, most attention has focused on the ErbB2 receptor. Now, in a recent report, it has been shown that ErbB3 is a critical partner for the transforming activity of ErbB2 in breast cancer cells. Importantly, the proliferative signals from this transforming complex appear to act via the PI-3 kinase pathway.

Source: Breast Cancer Research

DOI: 10.1186/bcr792

Authors: Elena Perez-Nadales, Alison C Lloyd

Institutions: MRC Laboratory for Molecular Cell Biology, University College London

Language: English

Topic: HER2/EGFR in Cancer Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,190