Year: 2013
Type: article
Abstract: Existing chemotaxis assays do not generate stable chemotactic gradients and thus--over time--functionally measure only nonspecific random motion (chemokinesis). In comparison, microfluidic technology has the capacity to generate a tightly controlled microenvironment that can be stably maintained for extended periods of time and is, therefore, amenable to adaptation for assaying chemotaxis. We describe here a novel microfluidic device for sensitive assay of cellular migration and show its application for evaluating the chemotaxis of smooth muscle cells in a chemokine gradient.
Source: BioMed Research International
DOI: 10.1155/2013/373569
Authors: Chen Zhang, Sunyoung Jang, Ovid C. Amadi, Koichi Shimizu, Richard T. Lee, Richard N. Mitchell
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
OpenAlex ID: W2132010158