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The benefit-risk consideration in long-term use of alternate-day, low dose aspirin: focus on colorectal cancer prevention.

Year: 2014
Type: article
Abstract: Summary Evidence has recently showed that aspirin may provide prophylaxis for cancer, primarily colorectal cancer, but also gastric cancer as well as breast, ovarian, prostate, and lung cancer [1]. It is reported that the benefits increase with use duration and an earlier effect was shown in trials using higher doses [2,3]. However, these meta-analyses were limited to trials of daily aspirin use. Previous analyses from the Women’s Health Study (WHS) found no effect of alternate-day low dose aspirin on cancer risk, including colorectal cancer, over a mean follow up of 10 years [4]. Recently, the WHS published a follow up for cardiovascular and cancer outcomes since its active drug intervention in 2004 [5]. The extended study primarily aimed to examine long-term, a median 18-year follow-up effects of alternateday, low-dose aspirin on cancer risk, particularly colorectal cancer, in healthy women. 39,876 women aged 45 years or older were enrolled in a median 10-year intervention of aspirin or placebo, and 33,682 women were observed in a post-trial follow up through March 2012. Participants were sent annual supplies of monthly calendar packs containing aspirin or placebo in a blinded fashion during the intervention period. At 6 and 12 months and then yearly, participants were mailed questionnaires on drug adherence, adverse effects, non-study aspirin use, clinical endpoints, and risk factors. At the end of the active intervention, participants were opted in or out for further annual follow up. The results showed that over the entire follow-up period, aspirin had no effect on overall (hazard ratio [HR] 0.97, 95%CI 0.92-1.03, P=0.31),
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W2132478939
FWCI: 0.441
Cites: 9
Cited by: 2
Related to: 10