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Polymer–Drug Nanoconjugates

Year: 2013

Type: reference-entry

Abstract: It is expected that the field of polymeric nanomedicine will dramatically change the landscape of oncology in several important ways. Two strategies for loading drugs into nanoparticles have been used: to encapsulate drugs within nanoparticles via noncovalent bonds and to formulate nanoparticles using polymer‐drug conjugates. This chapter will examine the pros and cons of each strategy and will introduce new polymer–drug conjugates—called nanoconjugates—to address the challenges faced by both strategies. Also discussed in this chapter are topics related to regioselective polymer–drug conjugation chemistry,in vitroformulation and characterization, and preliminaryin vivostudies that highlight the potential clinical translation of nanoconjugates.

Source: Pharmaceutical Sciences Encyclopedia

DOI: 10.1002/9780470571224.pse494

Authors: Rong Tong, Li Tang, Nathan P. Gabrielson, Qian Yin, Jianjun Cheng

Institutions: Boston Children's Hospital, Harvard University, Massachusetts Institute of Technology, University of Illinois Urbana-Champaign

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2132574740

Cites: 106

Cited by: 2

Related to: 10