Work

Fluorescence Microscopy Demonstrates Enhanced Targeting of Telavancin to the Division Septum ofStaphylococcus aureus

Year: 2010

Type: article

Abstract: The cellular binding patterns of fluorescent conjugates of telavancin and vancomycin were evaluated in Staphylococcus aureus by fluorescence microscopy and ratio imaging analysis. Telavancin showed enhanced binding at the division septum compared to vancomycin. This result is consistent with observations that telavancin binds with higher affinity to lipid II than to d-Ala-d-Ala residues in the cell wall, thus demonstrating the preferential binding of telavancin to the site of active cell wall biosynthesis.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01609-09

Authors: Christopher S. Lunde, Charles H. Rexer, Stephanie R. Hartouni, Sabine Axt, Bret M. Benton

Institution: Theravance Biopharma (United States)

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2132629057

FWCI: 2.928

Cites: 16

Cited by: 30

Related to: 10