Mechanisms of Immunopathology in Murine Models of Central Nervous System Demyelinating Disease
Year: 2006
Type: article
Abstract: Many disorders of the CNS, such as multiple sclerosis (MS), are characterized by the loss of the myelin sheath surrounding nerve axons. MS is associated with infiltration of inflammatory cells into the brain and spinal cord, which may be the primary cause of demyelination or which may be induced secondary to axonal damage. Both the innate and adaptive arms of the immune system have been reported to play important roles in myelin destruction. Numerous murine demyelinating models, both virus-induced and/or autoimmune, are available, which reflect the clinical and pathological variability seen in human disease. This review will discuss the immunopathologic mechanisms involved in these demyelinating disease models.
Source: The Journal of Immunology
Authors: Anne M Ercolini, Stephen D Miller
Institution: Northwestern University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G244136814, Mechanisms of CD4+CD25+ T Regulatory Cells in EAE, G4818106044, G509473639, A Virus-induced Molecular Mimicry Model of MS, CNS Damage from Theiler's Virus Persistence: MS Model, Pathogenesis and Immunoregulation of PLP-Induced R-EAE, G647050514, Immunoregulation and Pathology of Chronic-Relapsing EAE, G90067601
OpenAlex ID: W2132730003