Work

Recent H3N2 Influenza Virus Clinical Isolates Rapidly Acquire Hemagglutinin or Neuraminidase Mutations When Propagated for Antigenic Analyses

Year: 2014

Type: article

Abstract: Prior to serological testing, influenza viruses are typically propagated in eggs or cell culture. Recent human H3N2 strains bind to cells with low avidity. Here, we isolated nine primary H3N2 viral isolates from respiratory secretions of children. Upon propagation in vitro, five of these isolates acquired hemagglutinin or neuraminidase mutations that increased virus binding to cell surfaces. These mutations can potentially confound serological assays commonly used to identify antigenically novel influenza viruses.

Source: Journal of Virology

DOI: 10.1128/jvi.01077-14

Authors: Benjamin S. Chambers, Yang Li, Richard L. Hodinka, Scott E. Hensley

Institutions: The Wistar Institute, University of Pennsylvania, Children's Hospital of Philadelphia

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Pennsylvania Department of Health, National Institutes of Health, Centers for Disease Control and Prevention, National Institute of Allergy and Infectious Diseases