Work

Interaction between nicotine and dopaminergic D1 receptor of dorsal hippocampus in the hole-board test of anxiety

Year: 2012

Type: article

Abstract: Findings: Nicotine (0.5 mg/kg) produced anxiogenic effect (P<0.001). Intra-CA1 injections of ineffective doses of SCH23390 reversed the anxiogenic effects induced by nicotine (P<0.001). Furthermore, co-administration of ineffective dose of SKF38393 plus ineffective dose of nicotine increased the anxiogenic effect of nicotine (P<0.001). Locomotion activity was unchanged when no drug was administered. Conclusion: The results indicated that dopamine D1 receptors of the dorsal hippocampus have modulatory role in the anxiogenic response induced by nicotine.

Source: The Journal of Qazvin University of Medical Sciences

Authors: Morteza Piri, M Nasehi, Fatemeh Mafi, Maryamu-sadat Shahin, M.R. Zarrindast

Institution: Islamic Azad University Ardabil

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2132909533

FWCI:

Cites: 25

Cited by: 4

Related to: 10