Work

Low Concentrations of HIV-1 DNA at Birth Delays Diagnosis, Complicating Identification of Infants for Antiretroviral Therapy to Potentially Prevent the Establishment of Viral Reservoirs

Year: 2014

Type: article

Abstract: Among infants exposed to human immunodeficiency virus type 1 (HIV-1), detection of viral infection at birth was increased by 39% (95% confidence interval, 19%-47%) by increasing DNA input from dried blood spots into polymerase chain reaction. Infants with low concentrations of HIV-1 at birth may be the best target population to evaluate whether immediate antiretroviral therapy can prevent long-term infection.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciu068

Authors: C. Mitchell, S. Dross, I. A. Beck, M. A. Micek, L. M. Frenkel

Institutions: University of Washington, Seattle Children's Research Institute, University of Wisconsin–Madison, Health Alliance International

Language: English

Topic: HIV/AIDS Research and Interventions

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases