Work

A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents

Year: 2000

Type: article

Abstract: A convenient synthesis of nonsymmetrical bivalent inhibitors of the serotonin transporter is described. The synthesis utilizes polymer-supported reagents that allow for rapid access to novel bivalent ligands without the need for isolation or purification of synthetic intermediates.

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/s0960-894x(00)00576-x

Authors: Amir P Tamiz, Paola Conti, Mei Zhang, Kenneth M Johnson, Alan P Kozikowski

Institutions: Georgetown University, Georgetown University Medical Center, The University of Texas Medical Branch at Galveston

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,880

Funders: National Institutes of Health, National Institute on Drug Abuse