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The Genomic Landscape of Breast Cancer as a Therapeutic Roadmap

Year: 2013
Type: article
Abstract: The application of high-throughput techniques to profile DNA, RNA, and protein in breast cancer samples from hundreds of patients has profoundly increased our knowledge of the disease. The etiologic events that drive breast cancer are finally coming into focus and should be used to set priorities for clinical trials. In this Prospective, we summarize some of the headline conclusions from 6 recent breast cancer "omics profiling" articles in Nature, with an emphasis on the implications for systemic therapy.
DOI: 10.1158/2159-8290.cd-12-0462
Language: English
Subfield: Cancer Research
Open Access status: green
Funders: Breast Cancer Research Foundation, Susan G. Komen, National Institutes of Health, U.S. Food and Drug Administration, National Human Genome Research Institute, National Cancer Institute, National Center for Research Resources
Awards: G1015085565, G1477722104, Conserved Biology of Tumor and Microenvironment in Breast Cancer Progression, G1565341982, G1569999668, G274336489, G2894286751, A Resource for Biomedical Mass Spectrometry, Gene Expression Patterns in Human Tumors Identified Using Transcript Sequencing
OpenAlex ID: W2133369878
FWCI: 9.518
Cites: 54
Cited by: 229
Related to: 10