Efficient Extension of Slipped DNA Intermediates by DinB Is Required To Escape Primer Template Realignment by DnaQ
Year: 2011
Type: article
Abstract: We show that Escherichia coli DinB polymerase, which creates single-base deletions, prefers to extend slipped DNA substrates with the skipped base at the -4 position. A DinB(Y79L) variant, which extends these substrates less efficiently in vitro, allows the proofreading function of polymerase III to reverse their formation in vivo.
Source: Journal of Bacteriology
DOI: 10.1128/jb.00005-11
Authors: James J. Foti, Graham C. Walker
Institution: Massachusetts Institute of Technology
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2133420047