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The Aging Immune System and Its Relationship with Cancer

Year: 2011

Type: article

Abstract: The incidence of most common cancers increases with age. This occurs in association with, and is possibly caused by a decline in immune function, termed immune senescence. Although the size of the T-cell compartment is quantitatively maintained into older age, several deleterious changes (including significant changes to T-cell subsets) occur over time that significantly impair immunity. This article highlights some of the recent findings regarding the aging immune system, with an emphasis on the T-cell compartment and its role in cancer.

Source: Aging Health

DOI: 10.2217/ahe.11.56

Authors: Anthony D Foster, Amogh Sivarapatna, Ronald E Gress

Institutions: National Cancer Institute, Center for Cancer Research, National Institutes of Health

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute