Work

Immunosuppressive treatment in multifocal motor neuropathy

Year: 1991

Type: article

Abstract: We report the results of immunosuppressive treatments of 13 patients with multifocal motor neuropathy and elevated titers of serum antibodies to the GM1 ganglioside. All patients failed to respond to oral prednisone. There was no clinical response in 4 patients treated with plasma exchange. Nine patients received cyclophosphamide, with clinical improvement and fall in antibody titers in 8. In 3 patients, cyclophosphamide was discontinued with ensuing clinical relapse and rise in the titers of serum anti-GM1 antibodies. These patients provide further evidence for the efficacy of cyclophosphamide therapy in patients with multifocal motor neuropathy.

Source: Annals of Neurology

DOI: 10.1002/ana.410300312

Authors: Eva L. Feldman, Mark B. Bromberg, James W. Albers, Alan Pestronk

Institutions: University of Michigan, Washington University in St. Louis

Language: English

Topic: Peripheral Neuropathies and Disorders

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, U.S. Public Health Service, National Institute of Neurological Disorders and Stroke