Serum adiposity-induced biomarkers in obese and lean children with recently diagnosed autoimmune type 1 diabetes
Year: 2014
Type: article
Study design: Observational Study
Abstract: BACKGROUND/OBJECTIVE: Obesity increases the risk of cardiovascular disease and diabetic complications in type 1 diabetes. Adipokines, which regulate obesity-induced inflammation, may contribute to this association. We compared serum adipokines and inflammatory cytokines in obese and lean children with new-onset autoimmune type 1 diabetes. SUBJECTS AND METHODS: We prospectively studied 32 lean and 18 obese children (age range: 2-18 yr) with new-onset autoimmune type 1 diabetes and followed them for up to 2 yr. Serum adipokines [leptin, total and high molecular weight (HMW) adiponectin, omentin, resistin, chemerin, visfatin], cytokines [interferon (IFN)-gamma, interleukin (IL)-10, IL-12, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha] and C-reactive protein (CRP) were measured at a median of 7 wk after diagnosis (range: 3-16 wk). RESULTS: Lean children were 71.9% non-Hispanic White, 21.9% Hispanic, and 6.3% African-American, compared with 27.8, 55.6, and 16.7%, respectively, for obese children (p = 0.01). Compared with lean children, obese children had significantly higher serum leptin, visfatin, chemerin, TNF-alpha and CRP, and lower total adiponectin and omentin after adjustment for race/ethnicity and Tanner stage. African-American race was independently associated with higher leptin among youth ≥10 yr (p = 0.007). Leptin levels at onset positively correlated with hemoglobin A1c after 1-2 yr (p = 0.0001) independently of body mass index, race/ethnicity, and diabetes duration. Higher TNF-alpha was associated with obesity and female gender, after adjustment for race/ethnicity (p = 0.0003). CONCLUSION: Obese children with new-onset autoimmune type 1 diabetes have a proinflammatory profile of circulating adipokines and cytokines that may contribute to the development of cardiovascular disease and diabetic complications.
Source: Pediatric Diabetes
DOI: 10.1111/pedi.12159
Authors: MJ Redondo, LM Rodriguez, MW Haymond, CS Hampe, EO Smith, A Balasubramanyam, S Devaraj
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Cellular pathways of inflammation in type 1 diabetes, CLINICAL SCIENTIST TRAINING PROGRAM, The role of amylin and GLP-1 mimetics in the treatment of children with T2DM, Arginine and Nitric Oxide Synthesis in the Pathogenesis of Ketosis-Prone Diabetes, Cellular pathways of inflammation in type 1 diabetes, Baylor Mentored Diabetes Investigator Award, Islet Cell Membrane Antibodies in Diabetes, General Clinical Research Center, Pathogenesis of Ketosis Prone Diabetes, Baylor Mentored Clinical Investigator Award, Texas Children's Hospital and Baylor College of Medicine TrialNet Clinical Center, Diabetes Research Center
OpenAlex ID: W2133811005