Work

Chemical assembly of N-glycoproteins: a refined toolbox to address a ubiquitous posttranslational modification

Year: 2013

Type: review

Abstract: Incremental developments in the chemistry of peptides, proteins and carbohydrates have enabled researchers to assemble entire glycoproteins with high precision. Based on sophisticated ligation chemistries pure glycoproteins bearing a single glycosylation pattern have become available. The impact of N-glycosylation on the function of glycoproteins is generally recognized but not well understood. Based on the recent advances in the synthesis of glycoproteins by chemical methods researchers can finally start to elucidate the various roles of carbohydrates in complex biomolecules in detail.

Source: Chemical Society Reviews

DOI: 10.1039/c3cs35485g

Authors: Carlo Unverzagt, Yasuhiro Kajihara

Institutions: University of Bayreuth, The University of Osaka

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: Japan Society for the Promotion of Science

Award: Chemical Synthesis of glycoproteins having complex type oligosaccharides and elucidation of oligosaccharide functions