Cell-Based Therapeutics: The Next Pillar of Medicine
Year: 2013
Type: article
Abstract: Two decades ago, the pharmaceutical industry-long dominated by small-molecule drugs-was revolutionized by the the advent of biologics. Today, biomedicine sits on the cusp of a new revolution: the use of microbial and human cells as versatile therapeutic engines. Here, we discuss the promise of this "third pillar" of therapeutics in the context of current scientific, regulatory, economic, and perceptual challenges. History suggests that the advent of cellular medicines will require the development of a foundational cellular engineering science that provides a systematic framework for safely and predictably altering and regulating cellular behaviors.
Source: Science Translational Medicine
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Identifying and characterizing small molecules from the human microbiome, Exploring Design Principles of Cellular Control Circuits, Antibiotics from nose and throat commensals that impact pathogen colonization, Natural products from a human-asssociated fungal pathogen, Immunomodulation of transplant rejection by Anti-CD3 mAb, Cellular Control: Synthetic Signaling/Motility (RMI), G8342628927, G8548556527, Diabetes Research Center
OpenAlex ID: W2133897272