Year: 2008
Type: review
Abstract: In human and experimental myocardial infarction (MI), cessation of blood supply leads to rapid necrosis of cardiac myocytes in the ischaemic heart. Immediately after injury, various intra- and intercellular pathways contribute to healing the myocardial wound in order to achieve tissue integrity and function. MI and the consequent loss of myocardium are the major aetiology for heart failure. Despite aggressive primary therapy, prognosis remains poor in patients with large infarction and severe left ventricular dysfunction. Thus, it would be highly desirable to improve healing of the cardiac wound to maintain structure and function of the heart. Healing in the heart occurs in overlapping phases. Herein, we review the inflammatory phase as a trigger of tissue formation.
Source: Cardiovascular Research
DOI: 10.1093/cvr/cvn292
Authors: S. Frantz, J. Bauersachs, G. Ertl
Institution: Universitätsklinikum Würzburg
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: Deutsche Forschungsgemeinschaft
Awards: G653862013, G7152521561
OpenAlex ID: W2134012941