Work

Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C

Year: 2009

Type: review

Abstract: Hepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-alpha), and their soluble receptors (e.g. soluble TNF-alpha receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with chronic hepatitis C.

Source: The Brazilian Journal of Infectious Diseases

DOI: 10.1590/s1413-86702009000500013

Authors: Alexandre Sampaio Moura, Ricardo Andrade Carmo, Antonio Lucio Teixeira, Manoel Otávio da Costa Rocha

Institution: Universidade Federal de Minas Gerais

Language: English

Topic: Hepatitis C virus research

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,600