Work

Prion variants, species barriers, generation and propagation

Year: 2009

Type: article

Abstract: Prion variants faithfully propagate across species barriers, but if the barrier is too high, new variants (mutants) are selected, as shown in a recent BMC Biology report. Protein sequence alteration can prevent accurate structural templating at filament ends producing prion variants.

Source: Journal of Biology

DOI: 10.1186/jbiol148

Authors: Reed B Wickner, Herman K Edskes, Frank Shewmaker, Dmitry Kryndushkin, Julie Nemecek

Institutions: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Language: English

Topic: Prion Diseases and Protein Misfolding

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,686

Funder: National Institutes of Health