Work

Rolling Circle Transcription of Tandem siRNA to Generate Spherulitic RNA Nanoparticles for Cell Entry

Year: 2012

Type: article

Abstract: Small interfering RNA (siRNA) holds great promise as a simple, yet powerful therapeutic strategy to knockdown the function of a particular gene. However, the major obstacle to the use of siRNA in clinical applications is the lack of an effective delivery system. Much effort has concentrated on developing methods to package or encapsulate siRNA with polymers or lipids. In a recent issue of Nature Materials, Paula Hammond and coworkers present an innovative approach to siRNA delivery based on the production of dense RNA “microsponges” that contain more than a half million copies of an siRNA precursor.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1038/mtna.2012.31

Author: Peixuan Guo

Institutions: University of Kentucky, Markey Cancer Center

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900