Aliskiren (tekturna), a novel antihypertensive approach to inhibition of the Renin-Angiotensin-aldosterone system.
Year: 2008
Type: article
Abstract: Hypertension is defined as a systolic blood pressure (BP) of 140 mm Hg or higher, a diastolic BP of 90 mm Hg or higher, or the need to take an antihypertensive drug.1 The prevalence of hypertension in America has reached epidemic proportions; almost 72 million adults (nearly one in three) have hypertension.2
The implications of this prevalence are devastating. Hypertension is strongly associated with ischemic heart disease and stroke, and the risk of mortality from these conditions is doubled with every increase of 20 mm Hg in systolic BP or of 10 mm Hg in diastolic BP. Even small increases in BP (values up to 130–139/85–89 mm Hg), when compared to normotensive levels (120/80 mm Hg or below), result in a doubling of the relative risk of cardiovascular disease.1
Source: PubMed
Authors: Julie Cromer, Simona Peker
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2134277408