Efficacy and Tolerability of the New Antiepileptic Drugs, II: Treatment of Refractory Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society
Year: 2004
Type: article
Abstract: PURPOSE: To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) [gabapentin (GBP), lamotrigine (LTG), topiramate (TPM), tiagabine (TGB), oxcarbazepine (OXC), levetiracetam (LEV), and zonisamide (ZNS)] in the treatment of children and adults with refractory partial and generalized epilepsies. METHODS: A 23-member committee, including general neurologists, pediatric neurologists, epileptologists, and doctors in pharmacy, evaluated the available evidence based on a structured literature review including MEDLINE, Current Contents, and Cochrane Library for relevant articles from 1987 to March 2003. RESULTS: All of the new AEDs were found to be appropriate for adjunctive treatment of refractory partial seizures in adults. GBP can be effective for the treatment of mixed seizure disorders, and GBP, LTG, OXC, and TPM for the treatment of refractory partial seizures in children. Limited evidence suggests that LTG and TPM also are effective for adjunctive treatment of idiopathic generalized epilepsy in adults and children, as well as treatment of the Lennox-Gastaut syndrome. CONCLUSIONS: The choice of AED depends on seizure and/or syndrome type, patient age, concomitant medications, and AED tolerability, safety, and efficacy. The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with refractory epilepsy and identify those seizure types and syndromes for which more evidence is necessary.
Source: Epilepsia
Authors: Jacqueline A. French, Andres M. Kanner, Jocelyn Bautista, Bassel Abou‐Khalil, Thomas Browne, Cynthia L. Harden, William H. Theodore, Carl Bazil, John Stern, Steven C. Schachter, Donna Bergen, Deborah Hirtz, Georgia D. Montouris, Mark Nespeca, Barry Gidal, William J. Marks, William R. Turk, James H. Fischer, Blaise Bourgeois, Andrew Wilner, R. Edward Faught, Rajesh C. Sachdeo, Ahmad Beydoun, Tracy A. Glauser
Institutions: Hospital of the University of Pennsylvania, University of Pennsylvania, Rush University Medical Center, Rush University, Cleveland Clinic, Vanderbilt University, Vanderbilt University Medical Center, Boston University, Boston Medical Center, Cornell University, Weill Cornell Medicine, National Institutes of Health, National Institute of Neurological Disorders and Stroke, NewYork–Presbyterian Hospital, Columbia University Irving Medical Center, Columbia University, Beth Israel Deaconess Medical Center, Harvard University, Rady Children's Hospital-San Diego, University of Wisconsin–Madison, UW Health University Hospital, University of California, San Francisco, University of California San Francisco Medical Center, University of Illinois Chicago, Nemours Children’s Clinic, Nemours Children's Clinic, Nemours Children's Clinic, Boston Children's Hospital, Rutgers, The State University of New Jersey, University of Alabama, University of Alabama at Birmingham, UAB Medicine, University of Michigan, University of Medicine and Dentistry of New Jersey, Cincinnati Children's Hospital Medical Center
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2134306772