Year: 2011
Type: review
Abstract: The p53 tumor suppressor is a sequence-specific transcription factor that undergoes an abundance of post-translational modifications for its regulation and activation. Acetylation of p53 is an important reversible enzymatic process that occurs in response to DNA damage and genotoxic stress and is indispensible for p53 transcriptional activity. p53 was the first non-histone protein shown to be acetylated by histone acetyl transferases, and a number of more recent in vivo models have underscored the importance of this type of modification for p53 activity. Here, we review the current knowledge and recent findings of p53 acetylation and deacetylation and discuss the implications of these processes for the p53 pathway.
Source: Protein & Cell
Authors: Christopher L. Brooks, Wei Gu
Institutions: Stemline Therapeutics (United States), Columbia University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: National Cancer Institute
Awards: Regulation of p53 acetylation and deacetylation in tumorigenesis., Mechanisms of Mdm2/Mdmx in repressing p53, Molecular Pathogenesis of Basal-like Breast Cancer, The role of ARF-BP1 in tumorigenesis, p53 - Regulators and Effectors, Mechanisms of p53 activation in tumorsuppression, Dynamic roles of HAUSP in p53/Mdm2 regulation
OpenAlex ID: W2134354168