Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance.
Year: 1979
Type: article
Abstract: Antigenic proteins may be absorbed intact. We report here results from in vivo experiments in mice showing that the prior feeding of protein antigen may reduce the subsequent absorption of that antigen without altering its elimination from the circulation. This may be a function of local immunity. We have also shown that the same feeding regime can paradoxically induce a state of systemic tolerance and suggest that the two phenomena contribute to the safe handling of these antigens.
Source: Gut
DOI: 10.1136/gut.20.2.121
Authors: E T Swarbrick, C R Stokes, J F Soothill
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2134373542