Work

Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models

Year: 2013

Type: review

Abstract: Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with cancer. In addition, these models can be used to study metastasis and tumor genetic evolution. This review examines the development, challenges, and broad use of these attractive preclinical models.

Source: Cancer Research

DOI: 10.1158/0008-5472.can-13-1069

Authors: Despina Siolas, Gregory J. Hannon

Institutions: Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York University

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences