Work

The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing

Year: 2009

Type: review

Abstract: GW182 family proteins interact directly with Argonaute proteins and are required for miRNA-mediated gene silencing in animal cells. The domains of the GW182 proteins have recently been studied to determine their role in silencing. These studies revealed that the middle and C-terminal regions function as an autonomous domain with a repressive function that is independent of both the interaction with Argonaute proteins and of P-body localization. Such findings reinforce the idea that GW182 proteins are key components of miRNA repressor complexes in metazoa.

Source: RNA

DOI: 10.1261/rna.1703809

Authors: Ana Eulalio, Felix Tritschler, Elisa Izaurralde

Institution: Max Planck Institute for Developmental Biology

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid