Work

Total Synthesis of (±)-Mitorubrinic Acid

Year: 2006

Type: article

Abstract: [reaction: see text] (+/-)-Mitorubrinic acid, a member of the azaphilone family of natural products, has been constructed in 12 steps. Key aspects of the synthesis include elaboration and oxidative dearomatization of an isocoumarin intermediate to provide the azaphilone nucleus with a disubstituted, unsaturated carboxylic acid side chain.

Source: Organic Letters

DOI: 10.1021/ol0610993

Authors: Maurice A. Marsini, Kristoffer M. Gowin, Thomas R. R. Pettus

Institution: University of California, Santa Barbara

Language: English

Topic: Biological Activity of Diterpenoids and Biflavonoids

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G4690600686, The Synthesis and Application of Novel Aromatic Materials