Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism
Year: 2009
Type: article
Abstract: The structure of LP2179, a member of the PF08866 (DUF1831) family, suggests a novel α+β fold comprising two β-sheets packed against a single helix. A remote structural similarity to two other uncharacterized protein families specific to the Bacillus genus (PF08868 and PF08968), as well as to prokaryotic S-adenosylmethionine decarboxylases, is consistent with a role in amino-acid metabolism. Genomic neighborhood analysis of LP2179 supports this functional assignment, which might also then be extended to PF08868 and PF08968.
Authors: Constantina Bakolitsa, Abhinav Kumar, Dennis Carlton, Mitchell D. Miller, S. Sri Krishna, Polat Abdubek, Tamara Astakhova, Herbert L. Axelrod, Hsiu-Ju Chiu, Thomas Clayton, Marc C. Deller, Lian Duan, Marc-André Elsliger, Julie Feuerhelm, Slawomir K. Grzechnik, Joanna C. Grant, Gye Won Han, Lukasz Jaroszewski, Kevin K. Jin, Heath E. Klock, Mark W. Knuth, Piotr Kozbial, David Marciano, Daniel McMullan, Andrew T. Morse, Edward Nigoghossian, Linda Okach, Silvya Oommachen, Jessica Paulsen, Ron Reyes, Christopher L. Rife, Henry J. Tien, Christina V. Trout, Henry van den Bedem, Dana Weekes, Qingping Xu, Keith O. Hodgson, John Wooley, Ashley M. Deacon, Adam Godzik, Scott A. Lesley, Ian A. Wilson
Institutions: Sanford Burnham Prebys Medical Discovery Institute, SLAC National Accelerator Laboratory, Joint Center for Structural Genomics, Stanford Synchrotron Radiation Lightsource, Scripps Research Institute, University of California San Diego, Genomics Institute of the Novartis Research Foundation
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Awards: G102163711, G1286236842, G1286251239, G1337544421, G1384768361, G1414775356, G1445641779, G1505794299, G1581387393, G1816284028, G1996474430, G2101401529, G2219523378, G222407312, G223002938, G2287611682, G2363639003, G2391189260, G2539837713, G262962599, G2857925935, G30714459, G3083819904, G3152346458, G3244038948, G3351052168, G3432487278, G365575497, G382641700, G402281873, G409777406, G419881185, G4259240498, G426311843, G42916606, G4385809619, G4501827968, G4597657575, G4847693919, G4866076653, G498139845, G5106849484, G5387317844, G5607048534, G5849692847, G5910536577, G6004781752, G650090426, G6767173602, G6848031779, JOINT CENTER FOR STRUCTURAL GENOMICS, G6918803902, G7186539832, G7368700025, G7374214904, G7583137537, G7688398576, G7757261926, G7787287669, G805243471, G9000030350, G9000047378, G9000319446, G969889393, G993149817
OpenAlex ID: W2134614805