Work

Development of Adult T-cell Leukemia in a Patient with Rheumatoid Arthritis Treated with Tocilizumab

Year: 2013

Type: article

Abstract: Tocilizumab (TCZ) was administered from 2004 to 2008 in a 52-year-old woman with rheumatoid arthritis (RA) refractory to methotrexate (MTX) as a clinical trial. TCZ therapy with MTX was resumed in March 2009 due to exacerbation of RA. The patient was an human T-lymphotropic virus type I (HTLV-I) carrier, and, in April 2011, a peripheral blood smear showed many atypical lymphocytes, thus leading to a diagnosis of adult T-cell leukemia (ATL). Complete remission of ATL was achieved with a standard therapeutic regimen.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.52.0468

Authors: Hideki Nakamura, Yukitaka Ueki, Shigeki Saito, Yoshiro Horai, Takahisa Suzuki, Tomoki Naoe, Katsumi Eguchi, Atsushi Kawakami

Institutions: Nagasaki University, Sasebo Chuo Hospital, Nagoya University, Sasebo City General Hospital

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2134650693

FWCI: 0.472

Cites: 17

Cited by: 25

Related to: 10