Direct glucocorticoid receptor–Stat5 interaction in hepatocytes controls body size and maturation-related gene expression
Year: 2007
Type: preprint
Abstract: The glucocorticoid receptor regulates transcription through DNA binding as well as through cross-talk with other transcription factors. In hepatocytes, the glucocorticoid receptor is critical for normal postnatal growth. Using hepatocyte-specific and domain-selective mutations in the mouse we show that Stat5 in hepatocytes is essential for normal postnatal growth and that it mediates the growth-promoting effect of the glucocorticoid receptor through a direct interaction involving the N-terminal tetramerization domain of Stat5b. This interaction mediates a selective and unexpectedly extensive part of the transcriptional actions of these molecules since it controls the expression of gene sets involved in growth and sexual maturation.
Source: Genes & Development
DOI: 10.1101/gad.426007
Institutions: German Cancer Research Center, Ludwig Boltzmann Institute for Cancer Research, Centre National de la Recherche Scientifique, Collège de France, Institut Pasteur, Research Institute of Molecular Pathology, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
Awards: Verbundprojekt: Nationales Genomforschungsnetz 2 - Genomnetz NeuroNet: Die Rolle des Glukokortikoidrezeptors in der Alkoholsucht , in der stressinduzierten Alkoholsucht und im Rückfall, G3802925141, G5352346632, G5836210418, Verbundprojekt: Nationales Genomforschungsnetz 2 - Genomnetz Herz-Kreislauf, Standort Berlin-Charité: Genetische und molekulare Mechanismen der hypertensiven Endorganschäden
OpenAlex ID: W2134658745