Work

Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat

Year: 1978

Type: article

Abstract: 2kartI&c*. 2hyCL $3): H299-~3~1j 1978.-Vascular permeability P in different cerebral regions of the conscious rat was determined, independently of blood flow, for "C tracers of glycerol, mannitol, sucrose, and inulin.A tracer was injected intravenously, arterial plasma concentrations were monitored, and regional brain concentrations were measured at specific times thereafter.A plasma-brain two-compartment model was used to calculate mean regional values of P, letting capillary area equal 240 cm"*g?P was Z-4 X 10+ cm * s-* for glycerol, 0.95-1.4X lop7 for mannitol, 2.53,O x 10mH for sucrose, and 1.0-1.4x IO-!) for inulin.Cerebrovascular permeability coefficients correspond to coef-

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.1978.235.3.h299

Authors: K. Ohno, K. D. Pettigrew, S. I. Rapoport

Institutions: Mercy Medical Center, Johns Hopkins Bayview Medical Center, National Institute on Aging, National Institute of Mental Health

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2134670490

FWCI: 9.737

Cites: 36

Cited by: 457

Related to: 10