Work

New insights of epithelial-mesenchymal transition in cancer metastasis

Year: 2008

Type: article

Abstract: Epithelial-mesenchymal transition (EMT) is a key step during embryonic morphogenesis, heart development, chronic degenerative fibrosis, and cancer metastasis. Several distinct traits have been conveyed by EMT, including cell motility, invasiveness, resistance to apoptosis, and some properties of stem cells. Many signal pathways have contributed to the induction of EMT, such as transforming growth factor-beta, Wnt, Hedgehog, Notch, and nuclear factor-kappaB. Over the last few years, increasing evidence has shown that EMT plays an essential role in tumor progression and metastasis. Understanding the molecular mechanism of EMT has a great effect in unraveling the metastatic cascade and may lead to novel interventions for metastatic disease.

Source: Acta Biochimica et Biophysica Sinica

DOI: 10.1111/j.1745-7270.2008.00443.x

Authors: Yadi Wu, Binhua P. Zhou

Institution: The University of Texas Medical Branch at Galveston

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, Core Research for Evolutional Science and Technology