Use of Nonsteroidal Anti-inflammatory Drugs and Survival Following Breast Cancer Diagnosis
Year: 2012
Type: article
Study design: Observational Study
Abstract: BACKGROUND: While there is accumulating evidence that use of nonsteroidal anti-inflammatory drugs (NSAID) decreases breast cancer risk, little is known about the impact of NSAIDs on survival after breast cancer diagnosis. METHODS: We assessed whether recent, prediagnostic NSAID use and lifetime cumulative aspirin use before diagnosis were associated with survival among 1,024 women with incident, primary, invasive breast cancer. RESULTS: Recent prediagnostic use of aspirin, ibuprofen, and acetaminophen and lifetime use of aspirin up to diagnosis were not associated with either all-cause mortality or breast cancer-specific mortality. Neither dose nor frequency of use was associated with risk. Associations were not different for pre- and postmenopausal women. CONCLUSION: In our data, prediagnostic NSAID use and lifetime cumulative aspirin use were not associated with breast cancer survival. IMPACT: Our findings do not support a role of NSAIDs prior to diagnosis in breast cancer survival.
Institutions: City College of New York, Roswell Park Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Wexner Medical Center, Fred Hutch Cancer Center, The Ohio State University, University at Buffalo, State University of New York
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2134757960