Work

Polymerization of a peptide-based enzyme substrate

Year: 2013

Type: article

Abstract: Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with reduced activity as enzymatic substrates.

Source: Chemical Communications

DOI: 10.1039/c3cc40472b

Authors: Michael E. Hahn, Lyndsay M. Randolph, Lisa Adamiak, Matthew P. Thompson, Nathan C. Gianneschi

Institution: University of California San Diego

Language: English

Topic: Advanced Polymer Synthesis and Characterization

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: Programming Pharmacokinetics in Vivo via In Situ Switching of Nanoscale Particle, EDAPT: Enzyme-Directed Assembly of Particle Theranostics, Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction, Training Clinical Scientists in Radiological Imaging