PTEN regulation of ERK1/2 signaling in cancer
Year: 2012
Type: review
Abstract: Mahandranauth A. Chetrama & Cimona V. Hinton*aa Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA, USAAddress for Correspondence: Cimona V. Hinton, Ph.D., Center for Cancer Research and Therapeutic Development, Clark Atlanta University, 223 James P. Brawley Drive, S.W, Atlanta, GA 30314, USA. Tel: (404) 880-8134. Fax: (404) 880-8065. E-mail: [email protected] its discovery, the tumor suppressor phosphatase and tensin homolog (PTEN) has become a molecule with a wide spectrum of functions, which is typically meditated through its lipid phosphatase activity; however, PTEN also functions in a phosphatase-independent manner. It is well established that PTEN regulates several signaling pathways, such as phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), janus kinase (JAK)/signal transducers and activators of transcription (STAT), focal adhesion kinase (FAK), and more recent, extracellular signal-regulated kinase (ERK)1/2, where activation of these pathways typically leads to cancer development and progression. In regard to most of these pathways, the underlining molecular mechanism of PTEN-mediated regulation is well established, but not so much for the ERK1/2 pathway. Indeed, accumulating evidence has shown an inverse correlation between PTEN expression and ERK1/2 in several malignancies. However, the detailed mechanism by which PTEN regulates ERK1/2 is poorly understood. In this review, we discuss the role of PTEN in regulating ERK1/2 by directly targeting shc/Raf/MEK and PI3K/AKT cascades, and a putative cross-talk between the two.
Institution: Clark Atlanta University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2134802402