Year: 2014
Type: article
Abstract: Neddylation is crucial for the degradation of certain proteins. However its role in regulating T cells is unknown. Neddylation is mediated by cullin-RING ligase (CRL) protein complex, an E3 ubiquitin ligase and its critical adapter element, SAG protein (sensitive to apoptosis gene protein). We explored the role of SAG and thus neddylation in T cells by utilizing two different, but complementary approaches, namely, genetic knock-out and chemical inhibition with small molecule. The T cell specific SAG KO animals were generated by crossing B6 SAGfl/fl mice with B6 LCK-Cre mice.
Institutions: University of Michigan, Michigan Medicine, U-M Rogel Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2134817568