Work

Genetically modified mice for the study of apolipoprotein B

Year: 1998

Type: article

Abstract: Over the past five years, several laboratories have used a variety of transgenic and gene-targeted mice to study apoB. These studies have helped in 1) generating new mouse models suitable for investigating the genetic and environmental factors affecting atherogenesis; 2) providing systems for investigating apoB structure/function relationships; 3) understanding the regulation of apoB gene expression in the intestine; 4) delineating a critical role for apoB expression in mouse embryonic development; 5) yielding insights into the "physiologic rationale" for the existence of the two different forms of apoB, apoB-48 and apoB-100, in mammalian metabolism; and 6) providing basic insights into mechanisms involved in the human apoB deficiency syndrome, familial hypobetalipoproteinemia.

Source: Journal of Lipid Research

DOI: 10.1016/s0022-2275(20)32560-8

Authors: Edward Kim, Stephen G. Young

Institutions: Gladstone Institutes, University of California, San Francisco

Language: English

Topic: Lipid metabolism and disorders

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430