Work

Ascorbic Acid Improves Vascular Permeability in Experimental-Induced Diabetic Rats

Year: 2005

Type: article

Abstract: Background: The most devastating manifestations of diabetes mellitus are vascular complications. Although there are many factors involved in the pathogenesis of diabetic vasculopathy, many studies suggest a role for glucose–induced oxidative stress. Studies in animal models, have demonstrated that the administration of antioxidants restores normal endothelial functions. The study was designed to examine the possible beneficial effects of ascorbic acid, which have antioxidant properties, on vascular permeability in the duodenum of rats with streptozotocin-induced diabetes. Methods: Female adult rats were divided into two control and three diabetic groups. Diabetes was induced by a single injection of streptozotoci n (55 mg/kg, ip). One control and two diabetic groups received ascorbic acid in drinking water (800 mg/kg). Diabetic groups received ascorbic acid either as therapeutic for 4 weeks, starting after the induction of diabetes or as combination therapy for 8 weeks starting 3-4 weeks before the induction of diabetes. Vascular permeability was estimated by measuring the extravasations of Evans blue dye and water content of duodenal tissue. Results: As compared to the control group, diabetic animals significantly increased both Evans blue extravasations and water content by 202%. Ascorbic acid, used as treatment or in combination therapy, similarly restored these two variables to normal level.

Source: Iranian journal of medical sciences

Authors: Mohammad Khaksari, K. Shafiee, Merat Mahmoudi, Asadi Karam Gh.R.

Institutions: Kerman University of Medical Sciences, Vali Asr University of Rafsanjan, Rafsanjan University of Medical Sciences

Language: English

Topic: Vitamin C and Antioxidants Research

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $350

OpenAlex ID: W2134998260