Work

DNA methylation of viruses infecting a eukaryoticChlorella-like green alga

Year: 1985

Type: article

Abstract: The genomic DNAs of the eukaryotic Chlorella-like green alga, strain NC64A, and eleven of its viruses all contain significant levels of 5-methyldeoxycytidine. In addition, the host DNA as well as six of the viral DNAs also contain N6-methyldeoxyadenosine. At least some of the methylated bases in the host reside in different base sequences than the methylated bases in the viruses as shown by differential susceptibility to restriction endonuclease enzymes. This suggests that the viruses encode for DNA methyltransferases with sequence specificities different from that of the host enzyme.

Source: Nucleic Acids Research

DOI: 10.1093/nar/13.10.3471

Authors: James L. Van Etten, Anne M. Schuster, Lois Girton, Dwight E. Burbank, David Swinton, Stanley Hattman

Institutions: University of Nebraska–Lincoln, University of Rochester

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Energy, National Institute of General Medical Sciences

Awards: G2339259819, G6942631888, G969889393