Markers of Inflammation and Immunosuppression as Predictors of Organ Failure in Human Acute Pancreatitis
Year: 2005
Type: dissertation
Abstract: Acute pancreatitis is an acute inflammation of the pancreas initiated by intracellular activation of pancreatic digestive enzymes.It is characterised by local and systemic activation of inflammatory cells, with overproduction of pro-inflammatory mediators.Systemic inflammation is accompanied by development of an anti-inflammatory counter-reaction that may result in impaired host immunity.It is believed that these inflammatory mediators play a significant role in the progression of local pancreatic inflammation into systemic disease with involvement of other organ systems.Usually acute pancreatitis is a mild, self-limited disease.However, some 20 to 30% of patients develop severe disease, with local pancreatic complications or systemic organ dysfunction or both.Because the development of vital organ failure is the major cause of morbidity and mortality in acute pancreatitis, early identification of patients likely to develop organ failure would be of clinical value.The aim of the present study was to find markers to predict development of organ failure as well as give insight into the development of immunosuppression in patients with acute pancreatitis.
Source: Työväentutkimus Vuosikirja
Author: Panu Mentula
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2135091625