Year: 2010
Type: article
Abstract: S mall biochemicals are the end result of all the regulatory complexity present in a cell, tissue, or organism, including transcriptional regulation, translational regulation, and posttranslational modifications.Metabolic changes are thus the most proximal reporters of the body's response to a disease process or drug therapy.In 1971, Robinson and coworkers 1 conceived the core idea that information-rich data reflecting the functional status of a complex biological system resides in the quantitative and qualitative pattern of metabolites in body fluids.In the same year, Horning and Horning 2 first used the term metabolic profiling to describe the output of a gas chromatogram from a patient sample.This new approach to the quantitative metabolic profiling of large numbers of small molecules in biofluids was ultimately termed "metabonomics" by Nicholson et al 3 and "metabolomics" by others.
Authors: Gregory D. Lewis, Robert E. Gerszten
Institutions: Harvard University, Massachusetts General Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2135120744