Work

Calcineurin Promotes Infection of the Cornea by Candida albicans and Can Be Targeted To Enhance Fluconazole Therapy

Year: 2006

Type: article

Abstract: In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00393-06

Authors: Chiatogu Onyewu, Natalie A. Afshari, Joseph Heitman

Institutions: Duke University, Duke Medical Center

Language: English

Topic: Ocular Infections and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Research to Prevent Blindness, National Institutes of Health, National Institute of Allergy and Infectious Diseases