Work

Dynamics of Magnetic Nanoparticle-Based Contrast Agents in Tissues Tracked Using Magnetomotive Optical Coherence Tomography

Year: 2009

Type: article

Abstract: Magnetomotive optical coherence tomography (MM-OCT) is an important tool for the visualization and quantitative assessment of magnetic nanoparticles in tissues. In this study, we demonstrate the use of MM-OCT for quantitative measurement of magnetic iron oxide nanoparticle transport and concentration inex vivomuscle, lung, and liver tissues. The effect of temperature on the dynamics of these nanoparticles is also analyzed. We observe that the rate of transport of nanoparticles in tissues is directly related to the elasticity of tissues, and describe how the origin of the MM-OCT signal is associated with nanoparticle binding. These results improve our understanding of how iron oxide nanoparticles behave dynamically in biological tissues, which has direct implications for medical and biological applications of targeted nanoparticles for contrast enhancement and therapy.

Source: IEEE Journal of Selected Topics in Quantum Electronics

DOI: 10.1109/jstqe.2009.2029547

Authors: Renu John, Eric J Chaney, Stephen A Boppart

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering