PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells
Year: 2012
Type: article
Abstract: Peptide nucleic acid (PNA) inhibitors of miR-221-3p (CU-PNA-221) and miR-466l-3p (CU-PNA-466) demonstrated changes in inflammatory responses. Suppression of inflammatory signalling was unexpected and further investigation led to the identification of calmodulin as a novel target of miRNA-466l-3p. These studies demonstrate that exogenous agents may suppress neuroinflammation mediated by microglial cells.
Source: Chemical Communications
DOI: 10.1039/c2cc36540e
Authors: Peter N. Brown, Hang Yin
Institution: University of Colorado Boulder
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Transforming Clinical Pain Control by Targeting a Novel Non-Neuronal Receptor, Probing Opioid-Induced Glial Activation with Peptide Antagonists, Optimizing the Clinical Efficacy of Opioids by TLR4 Blockade, Exogenous Chemical Probes of TLR-Mediated Neuroinflammation, G5925976606, G6410635432, G6457977569, Developing Small-Molecule Probes for Opioid-Induced Glial Activation, G7855982944
OpenAlex ID: W2135556848