Year: 2009
Type: review
Abstract: Alzheimers disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and agerelated changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD. Keywords: Alzheimer's disease, retinoid, retinoic acid receptors, inflammation, immunology, regulatory T cell, neurodegeneration
Source: Current Alzheimer Research
Authors: K. Shudo, H. Fukasawa, M. Nakagomi, N. Yamagata
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2135650301