Work

Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia

Year: 2015

Type: review

Abstract: Acute lymphoblastic leukemia (ALL) has been generally considered a genetic disease (disorder) with an aggressive tumor entity of highly proliferative malignant lymphoid cells. However, in recent years, significant advances have been made in the elucidation of the ALL-associated processes. Thus, we understand that histone acetylation is involved in the permanent changes of gene expression controlling ALL developmental outcomes. In this article, we will focus on histone acetylation associated with ALL, their implications as biomarkers for prognostic, and their preclinical and clinical applications.

Source: Clinical Epigenetics

DOI: 10.1186/s13148-015-0151-8

Authors: Cheng Zhang, Jiang F. Zhong, Andres Stucky, Xue-Lian Chen, Michael F. Press, Xi Zhang

Institutions: Army Medical University, Xinqiao Hospital, University of Southern California

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890